Scientific Program

Day 1 :

  • Neuromuscular Disorders
Speaker
Biography:

Rekha Patel has her expertise in the area of PKR regulated cell apoptosis in response to cellular stress. Her research on biochemical and molecular pathways that regulate cellular survival after stress signals has been central to understanding the etiology of dystonia 16 . She has built this model after years of experience in research on PKR regulated signaling pathways. Her work has provided a groundwork to understand the common pathways that are dysfunctional in various forms of dystonias. Her pioneering work has offered a novel paradigm for more investigations in basic molecular pathways in dystonias and also for therapeutic interventions that may work for different dystonias.

Abstract:

Dystonia is an inherited neuromuscular movement disorder that can result from mutations in more than 25 different genes. The patients suffer from inability to control their dystonic, often sustained repetitive movements, and have a compromised posture. One type of primary dystonia, the early onset dystonia 16 (DYT16), has been shown to be result from various mutations in the PACT (also known as PRKRA) gene that has been well characterized for its role in regulating apoptosis in response to cellular stress.

Under conditions of viral, oxidative, or endoplasmic reticulum stress, the cellular apoptosis has been shown to be regulated by prolonged translation inhibition resulting from kinase activity targeting the eukaryotic translation initiation factor 2 alpha. Events leading to eIF2 alpha phosphorylation in response to cell stress are attributed to interactions between three double stranded RNA binding proteins: PACT, TRBP, and PKR. These proteins interact with each other forming homo- and heterodimers to impact cellular fate in response to stress signals. PACT is a protein activator of PKR, a serine-threonine kinase involved in innate immunity. PACT-PKR interaction is essential for facilitating apoptosis; whereas, transactivation RNA binding protein (TRBP) serves as a PKR inhibitor via PACT-TRBP and TRBP-PKR heterodimerization. We investigated the altered protein-protein interactions between PACT, PKR, and TRBP resulting from various mutations in DYT16 patients, and for the first time in a mouse model of DYT16. Using various biochemical techniques, we characterized how these mutations influence PACT’s function during stress response to regulate apoptosis. By utilizing DYT16 patient samples as well as an analogous mouse model with dystonia we are attempting to better understand how PACT mutations may lead to early onset dystonia. Our research highlights the insight obtained by applying biochemical, and molecular analysis to patient cells and mouse models to understand the etiology and pathophysiology of dystonia.

Luca Mesin

Polytechnic University of Turin, Italy

Title: Reduction of crosstalk in surface electromyogram by optimal spatio-temporal filtering
Speaker
Biography:

Luca Mesin has done his Master’s degree in Electronics Engineering in 1999, PhD in Applied Mathematics in 2003. He is an Associate Professor in Biomedical Engineering at Polytechnic University of Turin, Italy. He is the Head of the research group on Mathematical Biology and Physiology. His research activities are devoted to the processing of signals or images extracted from biological and physiological systems and to the development of mathematical models for the interpretation of the recorded data. Applications are mainly focused on the investigation of biological systems or on the development of new biomedical tools. Recent works concern the simulation of spiral waves using a model of electromechanical coupling in the heart, the investigation of the central venous pressure, the processing of multiple data reflecting the responses of the autonomous nervous system and the simulation and processing of bioelectric signals.

 

Abstract:

Crosstalk can pose limitations in the applications of surface electromyogram (EMG). Its reduction can help in the identification of the activity of specific muscles. The selectivity of different spatial filters was tested in the literature both in simulations and experiments, but their performances are affected by many factors (e.g., anatomy and dimension/location of the electrodes). Moreover, they reduce crosstalk by decreasing the detection volume, recording data that represent only the activity of a small portion of the muscle of interest. In this study we propose an adaptive approach, which filters both in time and among different channels, providing a signal that maximally preserves the energy of the EMG of interest and discards that of nearby muscles (increasing the signal to crosstalk ratio, SCR). Tests with simulations and experimental data show an average increase of the SCR of about 2 dB with respect to the SD or DD data processed by the filters. The method is applied to few signals, proving its potential in applicative studies (e.g., clinics, gate analysis, and prosthesis control) where a limited number of non-selective channels are used. 

Mohammad Wasay

The Aga Khan University, Karachi, Pakistan

Title: Arbovirus infections of nervous system – trends and threats
Biography:

Abstract:

Arthropod-borne viruses (arboviruses) are among the most important international infectious threat to human nervous system. The neurological diseases that may be transmitted to humans in the traditional way by arthropods include meningitis, encephalitis, myelitis, encephalomyelitis, neuritis (including anterior horn cells and dorsal root ganglia), and myositis. Arboviruses are distributed worldwide.  However, different species have predilection for different geographical areas. Arboviruses are transmitted among vertebral hosts by blood feeding arthropod vectors including mosquitoes, biting flies, mites, nits and ticks. Some of the well-known encephalitides include West Nile encephalitis (WNE), Dengue fever encephalitis (DFE), St. Louis encephalitis (SLE), Japanese encephalitis (JE), Toscana encephalitis (TOE), Crimean-Congo hemorrhagic fever (CCHF), Chickeungunya virus encephalitis (CHIKV), Eastern equine encephalitis (EEE), and Western equine encephalitis (WEE). The keys to prevention of arboviral encephalitis include reduction of vector prevalence, reduction of amplifying of host susceptibility, avoidance of vector and reduction in human susceptibility through the use of insect repellants or immunization. With the widespread resistance to chemical control of vectors, novel methods like genetic control of vector populations are becoming increasingly important. The case fatality rate can range from <1% for LCE to as high as 70% in EEE.  The case fatality rate for JEE and SLE is up to 30%.  Neurological sequelae of arboviruses can result in permanent disability in as high as 90% of affected individuals depending on the virulence and type of the virus.

 

 

 

Table 1. Common arboviruses with their geographical distribution and vectors

Family

Virus

Vector

Geographical Distribution

Togaviridae

 

 

 

 

Eastern Equine Encepahlitis Virus

Mosquito (Culiseta, Aedes)

Eastern and Gulf coasts of USA, Carribean islands, Central America and northeast coast of South America

Western Equine Encephalitis Virus

Mosquito

(Culiseta, Culex)

Midwest and Western USA, Canada

Venezuelan Equine Encephalitis Virus

Mosquito

(Aedes, Culex)

South and Central America, Southeast and Southwest of USA

Chikungunya Virus

Mosquito

(Aedes)

Africa, India, Southeast Asia

Flaviviridae

 

 

 

 

St. Louis Encephalitis Virus

Mosquito

(Culex)

North America, Central America and South America

Japanese Encephalitis Virus

Mosquito

(Culex)

Japan, Northeast Asia, Southeast Asia, Central Asia and Indian Subcontinent

West Nile virus

Mosquito

(Culex)

Africa, Mediterranean region, central Asia, India, Europe, North America, Central and South America

Dengue Fever Virus

Mosquito

(Aedes)

Asia, tropical and subtropical regions of the world

Murray Valley Encephalitis Virus

Mosquito

(Culex, Aedes)

Australia, New Zealand, New Guinea

Bunyaviridae

 

 

 

 

California Encephalitis Virus

Mosquito

(Aedes)

Western USA

 

La Crosse Encephalitis Virus

Mosquito

(Aedes)

Midwest and eastern USA

 

Toscana Encephalitis Virus

Sand fly

(Phlebotomus)

Europe, North Africa

 

Rift Valley Fever Virus

Mosquito

(Culex, Aedes and others)

East Africa, South Africa Nile valley, Saudi Arabian peninsula

 

Crimean-Congo Hemorrhagic Fever Virus (Nairovirus)

Ticks

(Hyalloma, Ixodid)

Africa, Europe, Asia

Reoviridae

 

 

 

 

Colorado Tick Fever Virus

Ticks

(Dermacentor)

Rocky mountains of USA

 

Zhen-huan LIU

Nanhai Hospital for Women and Children, P.R.China

Title: A randomized controlled study and Evaluation of Children with Cerebral Palsy by Mind Acupuncture
Speaker
Biography:

Professor LIU ZHEN-HUAN,is the deputy manager of the Affiliated Maternity and Child Care Hospital of Guangzhou University of Chinese Medicine. The director of the Rehabilitation Child of hospital, and the Doctoral tutor of the Guangzhou University of Chinese Medicine. Prof. Liu became one of the paediatricians who received the special state Council allowance in China in 1994, was given the title of the prominent contribute youth expert by the Healthy Ministry of China in 2002, Prof. Liu got the honour of “model worker in nationwide”. In addition, Prof. Liu is also the adjunct professor of The Chinese university of Hong Kong and Pharmacy and the Health Institute of Indonesian Ministry of Health. Professor Liu is famous Pediatric Neurology /Acupuncture Doctor in The world

 

Prof. Liu has the experience of more than 30 years specializing in TCM- Western pediatrics studies and 20 years in rehabilitation for cerebral palsy. He founded the Rehabilitation Centre for Cerebral Palsy of the Affiliated Maternity and Child Care Hospital of Guangzhou University of Traditional Chinese Medicine,which is one of the world's renowned medical department. Since foundation, it has received more than 30,000 children with mental retardation and cerebral palsy from many countries, including China, the United States, Japan, the United Kingdom, New Zealand, Singapore, Poland, etc. Prof. Liu has also actively involved in the academic field. Since 1993, he has been giving seminars and academic exchange programs with world renowned scholars from Oxford University, Cambridge University, in the field of the application and assessment of the application of acupuncture treatment for brain and cerebral palsy rehabilitation in children throughout the world such as The United States, the United Kingdom, Spain, Australia, Norway, and so on.

Abstract:

To investigate the effects of clearing the mind Acupuncture in neural development and remediation of children with cerebral palsy. Methods: 200 cases of children with cerebral palsy were randomly divided into the treatment group (n = 100) and the control group (n = 100). The treatment group was given the combined therapy of acupuncture and rehabilitation training, The control group was only treated with rehabilitation training. A contrastive analysis of the therapeutic effect of acupuncture combined with rehabilitation training and pure rehabilitation training was made after a treatment course of 3 months. The Gross Motor Function Measure (GMFM) and Beijing Gesell Developmental Scale were adopted to assess the neural development and rehabilitation outcomes of the two groups. In addition, skull MRI was adopted to evaluate the plerosis of injured cerebral nerve after treatment. Results: The total effective rate in treatment group was 87%, significantly higher than the 55% in the control group. The children’s development quotient (DQ) tested by Gesell Developmental Scale and scores tested by GMFM in the treatment group was obviously higher than the control group (P < 0.01). The improving and curing rates presented by skull MRI in the treatment group were higher than the control group (P < 0.01). Conclusions: Clearing the Governor Vessel and refreshing the mind Needling could accelerate the recovery of injured brain nerve and the reconstruction of brain function. The acupuncture therapy could ameliorate both the motor development and cognitive development. On the other hand, the forward curative effect of acupuncture combined with rehabilitation training was significantly better than the pure rehabilitation training.

Zhen-huan LIU

Nanhai Hospital for Women and Children, P.R.China

Title: A randomized controlled study and Evaluation of Children with Cerebral Palsy by Mind Acupuncture
Speaker
Biography:

Professor LIU ZHEN-HUAN,is the deputy manager of the Affiliated Maternity and Child Care Hospital of Guangzhou University of Chinese Medicine. The director of the Rehabilitation Child of hospital, and the Doctoral tutor of the Guangzhou University of Chinese Medicine. Prof. Liu became one of the paediatricians who received the special state Council allowance in China in 1994, was given the title of the prominent contribute youth expert by the Healthy Ministry of China in 2002, Prof. Liu got the honour of “model worker in nationwide”. In addition, Prof. Liu is also the adjunct professor of The Chinese university of Hong Kong and Pharmacy and the Health Institute of Indonesian Ministry of Health. Professor Liu is famous Pediatric Neurology /Acupuncture Doctor in The world

 

Prof. Liu has the experience of more than 30 years specializing in TCM- Western pediatrics studies and 20 years in rehabilitation for cerebral palsy. He founded the Rehabilitation Centre for Cerebral Palsy of the Affiliated Maternity and Child Care Hospital of Guangzhou University of Traditional Chinese Medicine,which is one of the world's renowned medical department. Since foundation, it has received more than 30,000 children with mental retardation and cerebral palsy from many countries, including China, the United States, Japan, the United Kingdom, New Zealand, Singapore, Poland, etc. Prof. Liu has also actively involved in the academic field. Since 1993, he has been giving seminars and academic exchange programs with world renowned scholars from Oxford University, Cambridge University, in the field of the application and assessment of the application of acupuncture treatment for brain and cerebral palsy rehabilitation in children throughout the world such as The United States, the United Kingdom, Spain, Australia, Norway, and so on.

Abstract:

To investigate the effects of clearing the mind Acupuncture in neural development and remediation of children with cerebral palsy. Methods: 200 cases of children with cerebral palsy were randomly divided into the treatment group (n = 100) and the control group (n = 100). The treatment group was given the combined therapy of acupuncture and rehabilitation training, The control group was only treated with rehabilitation training. A contrastive analysis of the therapeutic effect of acupuncture combined with rehabilitation training and pure rehabilitation training was made after a treatment course of 3 months. The Gross Motor Function Measure (GMFM) and Beijing Gesell Developmental Scale were adopted to assess the neural development and rehabilitation outcomes of the two groups. In addition, skull MRI was adopted to evaluate the plerosis of injured cerebral nerve after treatment. Results: The total effective rate in treatment group was 87%, significantly higher than the 55% in the control group. The children’s development quotient (DQ) tested by Gesell Developmental Scale and scores tested by GMFM in the treatment group was obviously higher than the control group (P < 0.01). The improving and curing rates presented by skull MRI in the treatment group were higher than the control group (P < 0.01). Conclusions: Clearing the Governor Vessel and refreshing the mind Needling could accelerate the recovery of injured brain nerve and the reconstruction of brain function. The acupuncture therapy could ameliorate both the motor development and cognitive development. On the other hand, the forward curative effect of acupuncture combined with rehabilitation training was significantly better than the pure rehabilitation training.

Day 2 :

Day 3 :